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A metaanalysis of people who stopped GLP1 therapy without behavior change support found that, on average, they regained a meaningful share of the weight they had lost, with much of that regain happening in the first year after discontinuation

Other research pointed to oral tablets having a distinguishing feature, allowing for similar or better efficacy and similar tolerability compared with most injectable GLP-1s

Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss