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The secondary IVGTT-related pharmacodynamic (PD) endpoints were the change from baseline to end of treatment in AUC 010min , AUC 10120min and AUC 0120min with respect to C-peptide, insulin secretion rate (ISR), glucagon and insulin (only AUC 0120min )

Finally, enzymes not belonging to either group are categorized as other enzymes. We separated enzymes into these three classes for each dataset and virus using flux balance analysis (see Methods)

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