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In contrast, in AMYRs bound to rAmy 15 or the pramlintide analogue, San385 16 , an Asn at the equivalent peptide position (N14 rAmy ) adopts an upward rotamer that is exposed to the solvent environment and forms a H-bond with the backbone of L291 ECL2 (Fig

Part 1: exploration of antibody linker, payload loading, and payload molecular properties

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The LC-HRMS method for SCFA analysis is described in detail in the Supplementary Material