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Ruggiero A, Ariano A, Triarico S, Capozza MA, Romano A, Maurizi P, et al
Patients with PWS have lower circulating levels of brain-derived neurotrophic factor than individuals with simple obesity [30]
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Also, metabolites of VPA -oxidation (including propionic derivatives and 4-en-VPA) inhibit the mitochondrial CPS I, which is the first enzyme necessary for ammonia elimination via the urea cycle in the liver [19, 24]
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