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This is a common problem in multi-component products
These usually resolve by lowering frequency or concentration
The risk of systemic copper overload is negligible when used topically at recommended concentrations
While they are safe for almost everyone, some contraindications include those who are breastfeeding or pregnant, or who may have an allergy or sensitivity to any of the ingredients included in the shot
The British National Formulary (BNF), the British Society of Haematology Guidelines, NHS Clinical Knowledge guides, Integrated Care Board guidance notes such as this one from NHS Cambridgeshire and Peterborough, Vitamin B12 full guidance
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