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10.1186/1477-5956-7-47 79 KaoC

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While there is a strong evidence for the positive associations of estrogen and endometrial cancer, endometriosis, uterine fibroids, or breast cancer, the actions of progesterone remain unclear

These systems dynamically adjust dosing based on patient conditions, improving therapeutic precision and reducing adverse effects

Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury