This includes adults with an initial BMI of 30 kg/m 2 and above, or 27 to 29.9 kg/m 2 with at least one weight-associated comorbidity (e.g hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, prediabetes or T2DM)
Semaglutide works by mimicking the action of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels
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The phase 2 and phase 3 clinical trials use a systemic stepwise titration to gradually increase the retatrutide dose to help the body adjust and reach the therapeutically effective dose with minimal side effects
In the trials, the most weight loss occurred in individuals who received 5 mg to 15 mg per week over a few months