If pregnant, breastfeeding, or planning to conceive, discuss discontinuation of the medication with your healthcare provider at least two months prior to conception, as it may cause harm to the fetus
These kinases include Jun N-terminal kinase (JNK), inhibitor of nuclear factor kappa B kinase beta (IKK), and suppressor of cytokine signaling-3 (SOCS-3)
Participants receiving the maximum tolerated dose of Zepbound, combined with diet and exercise, experienced an average body weight loss exceeding 20% over 36 weeks, with sustained and additional weight loss observed in ongoing treatment
Monitoring Schedule For patients on GH secretagogues, a reasonable monitoring protocol includes IGF-1, fasting glucose, and HbA1c every 3 months for the first year, then every 6 months thereafter
Rossitch et al., 1991