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On the one hand, IL-1 exacerbates BBB disruption by downregulating tight junction protein Zonula Oc-cludens-1 (ZO-1), activating caspase-1 within the brain, and establishing a positive feedback loop that amplifies IL-1 production (36)

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Obesity is a significant independent risk factor contributing to numerous chronic conditions, including diabetes, hypertension, cardiovascular disease, and obstructive sleep apnea syndrome