beneficios y contraindicaciones de la l carnitina efectos secundarios efectos secundarios de l-carnitina title L-Carnitina: Mitos vs efectos secundarios de la l

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Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)

In the second subgroup (ALC add-on vs the same background drug), Gavrilova et al 19 observed AEs in 35% with ALC add-on versus 45% with antidepressant alone, and Ramezani et al 20 reported AEs in three patients (1 in ALC + sertraline, 2 in sertraline + placebo)

In particular, marked karyopyknosis of pyramidal cells of the hippocampus was observed, followed by moderate karyopyknosis and degeneration of Purkinje cells of the cerebellar cortex

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