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Previous work has shown that antibiotic-treated cells experience increased flux through metabolic pathways that lead to reactive metabolic by-products irrespective of the primary antibiotic-binding target, and these reactive metabolic by-products have been evidenced to contribute to antibiotic lethality 2,3,4,5,6,7,8,9,10,11,12,13,29

doi: 10.3390/metabo12040348 8 AngTBruceCRKowalskiGM

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Although biguanides, sulfonylurea, glitazones, and dipeptidyl peptidase 4 inhibitors have variable effects on cardiovascular events, sodium glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists have consistently shown safety and reduction in cardiovascular events in patients with established CVD

We discuss how to quickly recognize high-conflict individuals based on specific criteria and behaviors, helping listeners learn to spot their less obvious tactics