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After deep anaesthesia with isoflurane (Attane Vet, 1,000 mg g 1 , ScanVet, Piramal Critical Care) mice were decapitated and the brain was removed and submerged in ice-cold aCSF (124 mM NaCl, 5 mM KCl, 1.2 mM Na 2 HPO 4 2H 2 O, 2.7 mM CaCl 2 2H 2 O, 1.2 mM MgSO 4 (anhydrous)), 10 mM dextrose, 26 mM NaHCO 3 was adjusted to pH 7.4 and an osmolarity of 298302 mOsm kg 1 after saturation with carbogen (95% O 2 /5% CO 2 )

It typically begins within the first one to three days after an injection, peaks during the first week, and gradually diminishes over the next two to four weeks as your body adjusts to the medication

It is not the first time a potential link has been mooted patient leaflets for Mounjaro and Wegovy list it as a common side-effect

Multiple randomized controlled trials show that selenium supplementation (200 mcg daily as selenomethionine) can reduce TPO antibody levels and may slow autoimmune thyroid destruction

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