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[10] [4] Patients should contact their GP if they experience persistent or severe side effects, signs of allergic reaction (facial swelling, difficulty breathing, severe rash), or if symptoms of B12 deficiency (such as neurological symptoms, severe fatigue, or glossitis) do not improve after several weeks of supplementation

The integrity of the peptide depends on this gentle handling

Ask whether your symptoms match B12 deficiency, whether labs make sense, and how your medication history affects the plan, dosing, and follow-up

This is particularly relevant for people taking weight loss injections, such as GLP-1 agonists (e.g., Ozempic or Mounjaro), which can sometimes cause fatigue and a feeling of low energy

every 2 months for those with neurological symptoms Oral supplementation (50150 micrograms daily) may be appropriate for dietary insufficiency in patients with normal absorption