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Most experts suggest either starting with a loading phase dosage of 20 g/day for 5-6 days then dropping to a maintenance dose of 2-3 g/day 12 , or simply taking 3-5 g/day consistently without loading

RELATED: Wegovy for PCOS Migraine GLP-1 receptor agonists are being looked at for migraine, particularly in patients with obesity

Regulatory Status and FDA Approval Timeline Current FDA Status (as of June 2026) The FDA has not approved retatrutide for any indication as of June 2026

10.1007/s11695-012-0622-3 102 PetersenN.ReimannF.BartfeldS.FarinH

However, when weight regain occurs despite these hormonal changes, pharmacological augmentation with GLP-1 receptor agonists may help restore the metabolic advantages