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SIRT1, an NAD + -dependent class III histone deacetylase, regulates hepatic lipid metabolism through deacetylation of multiple transcription factors and metabolic enzymes, exerting a bidirectional effect on lipid homeostasis by inhibiting fat synthesis and promoting fatty acid oxidation

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J Clin Invest 133(3):e167952 Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs

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