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Efforts to refine and isolate salicin and salicylic acid took place throughout the middle- and late-19th century, and was accomplished by Bayer chemist Felix Hoffmann (this was also done by French chemist Charles Frederic Gerhardt 40 years earlier, but he abandoned the work after deciding it was impractical).[2] When the cinchona tree became scarce in the 1880s, people began to look for alternatives

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doi: 10.1128/iai.55.1.174-180.1987 137 JayaramanT.OndriasK.OndriaE.MarksA

Cell 73 , 354363 e353 (2019)