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On the other hand, in the toroidal pore model, peptides are also inserted perpendicularly in the lipid bilayer, but specific peptidepeptide interactions are not present (Wimley, 2010)

However, it would be interesting to see if similar bias occurs at central GLP-1r populations and whether this alters the synaptic and behavioral outcomes of GLP-1r agonism

This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

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Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis