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119 In addition, estradiol may influence the pathogenesis of male MDD patients

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Results demonstrated for the first time in the gastrointestinal that ionizing radiation persistently increases IGF1 and activates downstream PI3K/Akt and JAK2 signaling pathways, which may contribute to gastrointestinal functional alterations and carcinogenesis (Suman et al., 2015)

ER stress-related transcription factors ATF4 and ATF6 suppress LAMP2, essential for autophagosome-lysosome fusion, leading to impaired autophagic flux and cellular waste buildup