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Implicated specifically were increased angiogenesis, elevated vascular endothelial growth factor (VEGF) levels, upregulation of the early growth response (egr-1) gene, enhanced nitric oxide (NO) and NO-synthase (eNOS) stimulation, and counteraction of increased free radical formation [1]

Clinical grade silicone sheets of the same material used in the manufacture of Provox tracheo-esophageal prostheses were obtained from Atos Medical (Nottingham, UK)

It speeds up tissue repair, reduces inflammation, and boosts flexibility

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