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In addition to the neuropharmacological effects of GIPR antagonism, we also demonstrate that CNS GIPR KO prevents body weight gain under HFD challenge, supporting the role of CNS GIPR as a primary driver of body weight differences seen in the whole-body GIPR KO mouse 41

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Most of the studies involving ipamorelin have been conducted on animals

This imbalance results in the growth of inflammatory microorganisms, which can affect intestinal permeability and causie systemic inflammation through microbial translocation