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The only available human clinical trial data comes from Beck et al

When folate receptors are blocked (e.g., by folate receptor autoantibodies ), folate cant enter the brain efficiently, leading to: Developmental delays (speech, motor skills) Regression (loss of milestones in children) Seizures, irritability, sleep disorders Psychiatric symptoms (depression, psychosis) If you suspect that you have, or a loved one has any of the symptoms mentioned in the above, then it may be a very good idea to test for folate receptor autoantibodies with the FRAT test

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