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(2012, European Journal of Clinical Pharmacology) showed that after two weeks of berberine at 300mg three times daily, CYP2D6 activity dropped substantially (dextromethorphan metabolic ratio increased nine-fold), and midazolam concentrations rose 38 to 40% due to CYP3A4 inhibition

68 pounds down and I genuinely can't imagine who I'd be right now if I hadn't started. James F., 45 , 5'9" Start 278 lbs Current 204 lbs Lost 74 lbs Tried a well-known GLP-1 platform before this

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