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Gaudette, B

Research and Regulatory Status Approved Use (Native IGF-1): The native recombinant human IGF-1 (Mecasermin) is FDA-approved for growth failure in children with severe IGF-1 deficiency

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Previous investigations on mutant SOD1 transgenic mice revealed pathogenic processes in motor neurons, including protein misfolding, mitochondrial malfunction, and neurofilament buildup (Zhou et al., 2023)