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Cell 162 , 10781089 (2015)

This gene modulation not only supports recovery but also promotes long-term brain health

This was demonstrated for the endogenous MOR in striatal neurons (Haberstock-Debic et al., 2005) and occurred mainly in dendrites (Haberstock-Debic et al., 2003), in the human neuroblastoma cells SH-SY5Y (Nowoczyn et al., 2013) and in double KO MEF for arrestins transfected both with MOR and arrestin 3 (Groer et al., 2011)

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All participants received treatment for at least 52 weeks, with a maximum treatment duration of 104 weeks or until the study was completed to collect and evaluate major adverse cardiovascular events (MACE)