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129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons

In experimental models, GLP-1 receptor activation stimulates cyclic AMP (cAMP) production and activates protein kinase A (PKA), which subsequently influences gene transcription and cellular metabolism

Unlike other melanocortin peptides, PT-141 acts through central nervous system pathways rather than peripheral vascular mechanisms