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Future PCOS-specific economic studies should model not only weight and metabolic effects, but also fertility timing, washout-related delay, ART utilization, and potential rebound-related costs

Like other incretin-based therapies, it requires a stepwise titration protocol to balance effectiveness with safety, particularly gastrointestinal side effects that tend to appear at higher doses

[1] [3] Understanding these multisystem effects is essential when evaluating potential adverse effects, including fatigue, as the widespread distribution of GLP-1 receptors means these medications influence numerous physiological processes beyond glucose metabolism

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