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Sweeney et al., 2018)
Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation
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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)
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