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On May 20, 2024, HSK16149 was approved by the National Food and Drug Administration (NMPA) of China for treating PDNP in adults

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CR-D and AL were responsible for analyzing data from unpublished studies

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summarized that surgery and anesthesia can inhibit mitochondrial respiration, reduce ATP production, promote mitochondrial fission, cause Ca 2+ dysregulation, and increase oxidative stress in the brain all of which can lead to impaired synaptic function and even neuronal apoptosis (64)

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