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First, the initial generation of DPP4 inhibitors was not completely selective for DPP4, raising the possibility that some of the actions ascribed to use of these agents in vivo may reflect off-target activity (152)

The gut microbiota plays a significant role in this process by facilitating the reduction of bilirubin to urobilinogen

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All co-authors critically revised the manuscript draft, provided feedback, approved the final version of the manuscript, and approved its submission to Cell Death & Disease

They are used in the treatment of both Type 2 diabetes and obesity