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doi: 10.3389/fphar.2024.1432480 Received 14 May 2024 Accepted 22 October 2024 Published 28 November 2024 Volume 15 - 2024 Edited by Runping Liu, Beijing University of Chinese Medicine, China Reviewed by Yilin Yang, Yale University, United States Lubomir Skladany, F
The COR trials demonstrated approximately 5 to 6% weight loss beyond placebo at one year
However, whether these complementary effects translate into additive clinical benefit in patients with established HF remains to be confirmed in dedicated trials
20.8% said they went through a weight loss clinic/program
Common side effects may include: Nausea Diarrhea Vomiting Constipation Abdominal pain Indigestion Injection-site reactions Feeling tired Belching Hair loss Heartburn Rare, but serious side effects may include: Acute pancreatitis (including fatal, hemorrhagic, necrotizing) Acute gallbladder disease Acute kidney injury (typically secondary to dehydration) Severe gastrointestinal disease / delayed gastric emptying Hypoglycemia (especially with insulin or sulfonylureas) Hypersensitivity reactions including anaphylaxis and angioedema Pulmonary aspiration during anesthesia or deep sedation (delayed gastric emptying) Suicidal behavior and ideation (monitor) Diabetic retinopathy complications (in T2D clients with pre-existing retinopathy) Thyroid C-cell tumors (rodent data)
