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5 Novel targeted drugs Advancements in understanding the pathophysiological mechanisms of DN have led to the development of novel targeted therapies aimed at specific molecular pathways involved in nerve damage and pain transmission (Table 1 and Fig

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Without adequate intake of B12, vegans can easily develop deficiency over time, leading to symptoms such as fatigue, weakness, constipation, loss of appetite, weight loss, and nerve problems therefore the researchers recommend that vegans and vegetarians should add vitamin B12 to their diet by eating fermented foods, particular types of mushroom that contain the vitamin and B12-enriched vegetables