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The study found that patients treated with GLP-1RA, SGLT-2i, or their combination showed greater improvements in various cardiovascular and metabolic markers compared to those treated with insulin alone after 12 months
Concurrently, a reduction in the diversity of the intestinal microbiota was observed, characterized by a decrease in the relative abundance of Bacteroidetes and an increase in Proteobacteria
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Implications: GLP-1 analogs have gained significant attention following the approval of liraglutide (Saxenda) for obesity treatment
The reasoning is compelling
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