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first employed MBA as a MALDI matrix for the analysis of metal ions such as mercury (Hg 2+ ) and cadmium (Cd 2+ ), observing its benefits of low matrix background interference, enhanced signal intensity, and high reproducibility, making it suitable for highly sensitive metal detection

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That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification

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In the diet, L-carnitine is mainly found in red meat, making its required intake particularly difficult for vegans and vegetarians to meet