Vascular Regeneration & Angiogenesis Upregulates VEGF (vascular endothelial growth factor), supporting microcirculation and formation of new blood vessels in injured areas
Aim for at least 64 ounces (eight cups) of water daily, and increase this amount if you are experiencing GI side effects like diarrhea or vomiting
182 Its effects vary by cell type
McDonald, A.I., Shirali, A.S., Arag?n, R., Ma, F., Hernandez, G., Vaughn, D.A., Mack, J.J., Lim, T.Y., Sunshine, H., Zhao, P., Kalinichenko, V., Hai, T., Pelegrini, M., Ardehali, R., and Iruela-Arispe, M.L., "Endothelial Regeneration of Large Vessels is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities", Cell Stem Cell 23 (2): 210-225 (2018)
It is entirely possible that the PUF hub components could be displaying both target and pathway redundancy to tightly control the GSC proliferation vs differentiation decision (Table 1)