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Enhance glucose-dependent insulin secretion Reduce glucagon release Slow gastric emptying Increase satiety and reduce appetite Clinical applications include: Type 2 diabetes management Weight management in eligible patients Reduction of cardiovascular risk in selected patients Examples include: Semaglutide Liraglutide Dulaglutide Tirzepatide (dual GIP/GLP-1 receptor agonist) While these therapies have shown remarkable benefits, safe and effective use requires: Proper patient selection Monitoring for adverse effects Lifestyle modifications alongside therapy Guidance from healthcare professionals As healthcare continues to evolve, pharmacists play an important role in patient education, medication safety, and promoting evidence-based use of emerging therapies

FAQs referenced National Institutes of Health (NIH) Office of Dietary Supplements

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Have Tried Traditional Approaches Without Sustained Success: If you've lost weight through diet and exercise before but regained it, tried multiple commercial weight loss programs (Weight Watchers, Noom, Jenny Craig) without long-term success, have metabolic factors making weight loss extremely difficult (PCOS, hypothyroidism, menopause, insulin resistance), or have been told by doctors to lose weight for health reasons but struggle to do so through lifestyle alone, medical intervention may be the additional support needed

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AE-PCOS, Androgen Excess and PCOS Society