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Mechanistic insights from non-AD neuroinflammatory systems provide complementary evidence: interferon- (IFN-) robustly induces PD-L1 expression in human astrocytes and microglia, establishing a checkpointredox interface that suppresses excessive oxidative injury (Smith et al., 2023

For a supplement containing 100 IU of RRR-alpha tocopherol: 100 IU X 0.67 = 67 mg alpha-tocopherol Example 2

Expert Rev Mol Med 11:e17 Vargas MR, Pehar M, Cassina P, Beckman JS, Barbeito L (2006) Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75 NTR -dependent motor neuron apoptosis

Figure 5 Furthermore, pyridoxine is involved in myelin formation, serving as a cofactor in sphingolipid synthesis (58, 59)