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Fourteen products, including Tepezza, indicated for thyroid eye disease, and the leukemia drug Blincyto, achieved blockbuster status in 2025

The resin in the column was first washed with 5 column volumes (CVs) of buffer containing 20 mM HEPES, pH 7.4, 100 mM NaCl, 10% (v/v) glycerol, 5 mM MgCl 2 , 1 mM MnCl 2 , 25 M TCEP, 5 M tirzepatide, 0.1% (w/v) LMNG and 0.02% (w/v) CHS

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