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Cyanocobalamin Synthetic Vitamin B12 As we have discussed, for many years B12 supplements mainly contained cyanocobalamin , a synthetic form of B12 that is not directly bioactive and is only found naturally in the body or diet in minor traces

Until safety data exists, avoiding use during these periods is the only prudent approach

Therefore, we have determined that the SCOUT MD TM Delivery System meets the device category eligibility criterion at 419.66(c)(1)

Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically

Lyophilization removes water, which slows many degradation pathways and makes the material easier to ship and store