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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

For example, metalloproteinase inhibitor 4 (TIMP4) was upregulated by semaglutide in STEP 2 but not STEP 1

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The investigation revealed higher anticancer activity of the 5-FU loaded NLCs compared to the free 5-FU towards epidermal carcinoma cells and lower cytotoxicity towards human keratinocyte cells indicating that the NLCs were more effective at delivering the chemotherapeutic drug into the skin than the conventional hydrogel [411]

Where Does GLP-1 Fit In