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Furthermore, cMYC regulates the expression of PGC1 in breast cancer cells in response to Her2/IGF1 activation ( in vitro (Lyons et al., 2017)

It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)

They play a key role in cellular signaling, helping cells communicate and respond to their environment

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Key signs include diminished sexual desire, difficulty becoming aroused, prolonged time to reach orgasm, reduced orgasmic intensity or absence, vaginal dryness, painful intercourse, mood swings during intimacy, and chronic frustration after sexual activities