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It binds the GLP-1 receptor with high affinity and activates Gs-coupled cAMP/PKA signaling driving glucose-dependent insulin secretion, beta cell proliferation, delayed gastric emptying, and hypothalamic satiety signaling

Methionine synthase plays a role in the production of purines and pyrimidines, which are building blocks in DNA synthesis

Why It Matters More Than TRIUMPH-4 or TRANSCEND-T2D-1 Retatrutide already has two positive Phase 3 readouts in the bag: TRIUMPH-4 was a remarkable readout, but the population was narrow adults with obesity and knee osteoarthritis

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