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The growing prevalence of UGIT surgeries, including bariatric procedures such as Roux-en-Y gastric bypass (RYGB) [3,4,5], sleeve gastrectomy [6, 7], and duodenal switch[8], as well as other surgeries like esophagectomy [9]and gastrectomy [10],Nissen fundoplication [11]has drawn attention to this condition [12]

By targeting two hormonal pathways, it offers a more comprehensive approach to managing both food intake and the bodys ability to burn fat

But a closer look at their origins reveals a far less conventional story than most modern drugs

Ill highlight two that presented phase two results

In addition, a novel extraction procedure using pomegranate peel has been described for the obtaining of ellagic acid of the desired degree of purity essential for industrial uses because of the relatively low price and ease in its large-scale production (Lu and Yuan, 2008)