Prohibitin2/PHB2, transcriptionally regulated by GABPA, inhibits cell growth via PRKN/Parkin-dependent mitophagy in endometriosis

Patients should: Stay well hydrated Eat smaller, more frequent meals Avoid high-fat, greasy, or very spicy foods if experiencing nausea Report persistent or severe symptoms to their prescriber When to seek medical advice: Contact your GP or diabetes team for: Persistent vomiting or diarrhoea Concerns about medication effects or side effects Symptoms of hypoglycaemia if taking other diabetes medications Contact NHS 111 or seek urgent care for: Severe, persistent vomiting preventing fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Severe or persistent abdominal pain, particularly if radiating to the back (potential pancreatitis) Pain in the right upper abdomen, yellowing of skin/eyes (potential gallbladder issues) Sudden vision changes Allergic reactions (rash, difficulty breathing, facial swelling) Most patients find that side effects diminish significantly after 812 weeks, and the benefits of appetite control and metabolic improvement become more apparent

Pp 259 [online] Available at: Skogheim, T.S., Weyde, K.V.F., Engel, S.M., Aase, H., Suren, P., Oie, M.G., Biele, G., Reichborn-Kjennerud, T., Caspersen, I.H., Hornig, M., Haug, L.S
This schedule is intentional and reflects how the peptides AMPK pathway activation works
* Correspondence: Na Wu, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers