A reduction in receptor reserve could occur, in the absence of net reduction in total receptor number detected by typical ligand-binding assays, if there is redistribution of receptors from the plasma membrane to internal membranes
If you're also dealing with hormonal factors, the clinician can flag whether hormone evaluation makes sense and Healthspan offers both the Complete Male Hormone Panel and the Complete Female Hormone Panel to get baseline clarity before building out a protocol
Poor absorption in the body means only a small amount of glutathione reaches the cells where it is needed most, thereby limiting its potential therapeutic effects
A direct correlation between the efficiency of receptor phosphorylation and an agonists efficacy is consistent with evidence suggesting that G is a cofactor necessary for maximal GRK activation (DebBurman et al., 1996), although it is also likely that differences in agonist-induced conformational changes affect the accessibility of specific phosphorylation sites in the receptor
Psychopharmacology 186:177184 [DOI] [PubMed] [Google Scholar] Grecksch G, Just S, Pierstorff C, Imhof A-K, Gluck L, Doll C, Lupp A, Becker A, Koch T, Stumm R, et al
