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Other long-term toxicities Beyond the aforementioned target organ toxicities, long-term cohort studies have confirmed that platinum-based chemotherapy induces multiple delayed long-term adverse outcomes (manifesting years to decades post-chemotherapy, severely impairing cancer survivors long-term survival), including reproductive toxicity, cardiovascular toxicity, and elevated second primary neoplasm (SPN) risk

10.1152/ajpregu.00455.2006 210 WrbelA.Zapaa.KluzT.RogowskiA.MisiekM.JuszczakK.et al (2021)

Most of the End- used comments evaluate high quality chemicals

10.1016/j.anireprosci.2007.07.009 61

Suzuki, T., Motohashi, H