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Cisplatin nephrotoxicity: Cisplatin, a chemotherapy agent, causes renal damage partly by depleting glutathione in tubular cells

Pelletier JP, Fernandes JC, Brunet J, et al

This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

Although it was found that some vaccinated mice did succumb to the opioid drugs toxic effects, the researchers noted that it took much longer for the drug to impart its toxicity

10.1123/ijsnem.22.1.64 101