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It is important to note that confirmation of ferroptosis in erythrocytes can be challenging due to the impossibility to assess characteristic alterations of organelles (especially mitochondria, absent in mature RBCs) and the complex ferroptosis signaling requiring epigenetic, transcriptional, and post-translational regulation

Aging: Natural production typically begins to taper off once we hit our 20s and 30s, leaving us with less of a buffer against oxidative stress as the years go on

Horrigan LA, Kelly JP, Connor TJ (2006) Immunomodulatory effects of caffeine: friend or foe