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Anabolic Signaling in Preclinical Models In preclinical models, activation of this pathway is associated with several downstream signaling events: increased protein synthesis via mTOR activation, stimulation of satellite cells that contribute to muscle fiber development, and inhibition of the FOXO pathway, which under normal conditions promotes protein breakdown

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[ 1 ] suggested that, without histologic signs of malignancy, adjuvant treatment should not be performed and only strict radiologic and clinical follow-up is required