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It can be depleted during periods of stress, illness, or intense exercise

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| 2022 | Nutrients 4Amino acids: metabolism, functions, and nutrition | Wu | 2009 | Amino Acids 5Effects of 12 Weeks of Essential Amino Acids (EAA)-Based Multi-Ingredient Nutritional Supplementation on Muscle Mass, Muscle Strength, Muscle Power and Fatigue in Healthy Elderly Subjects: A Randomized Controlled Double-Blind Study | Negro et al

Animal studies indicate that serine may increase glutathione production by increasing the availability of cysteine while also reducing epigenetic changes associated with tumor development