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Animal studies found no deaths even at doses 1,000 times higher than typical therapeutic use (Sikiric et al., 2014)

On the other hand, similar intervention in combination with controlled hyperinsulinemia (~ 150mIU/L) elevates TC in skeletal muscle by ~ 15% [24, 25]

Specifically, levels of docosahexaenoic acid (DHA)the most abundant PUFA in the central nervous systemare significantly reduced in the hippocampus and cortex of AD patients (68, 71)

We need studies on humans to establish its safety and efficacy

First, due to the lack of detailed individual information regarding sex, mental and physical conditions, and other concomitant diseases, subgroups that may show more beneficial effects of antioxidants could not be selected ( Conclusion In summary, this MR study provides genetic evidence of a causal association between antioxidants and multiple cancer risks in Europeans